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Endotoxins pyrogens, LAL testing and depyrogenation

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Published by Informa Healthcare in New York .
Written in English

Subjects:

  • Endotoxins -- Analysis.,
  • Pyrogens -- Analysis.,
  • Limulus test.,
  • Drugs -- Microbiology.,
  • Endotoxins -- analysis.,
  • Pyrogens -- analysis.,
  • Infusions, Parenteral -- standards.,
  • Limulus Test.

Book details:

Edition Notes

Includes bibliographical references and index.

Statement[edited by] Kevin L. Williams.
SeriesDrugs and the pharmaceutical sciences -- v. 167
ContributionsWilliams, Kevin L.
Classifications
LC ClassificationsQP632.E4 P43 2007
The Physical Object
Paginationp. ;
ID Numbers
Open LibraryOL17850207M
ISBN 100849393728
ISBN 109780849393723
LC Control Number2007005326

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Book Description. This source expertly examines the discovery, biological structure, control, and continued clarification of endotoxin from a parenteral manufacturing perspective, with in-depth discussion of state-of-the-art technologies involving Limulus amebocyte lysate (LAL) such as assay development, automation, depyrogenation. Completely revised and expanded, this Third Edition contains.   This book provides invaluable insight and understanding into pyrogens and bacterial endotoxins. As an industrial microbiologist, this book has proved it value time and again when questions arise about the source and significance of endotoxin issues.5/5(1). Endotoxins: Pyrogens, LAL Testing and Depyrogenation (Drugs and the Pharmaceutical Sciences Book ) 3rd Edition, Kindle Edition by Kevin L. Williams (Editor) › Visit Amazon's Kevin L. Williams Page. Find all the books, read about the author, and more. 5/5(2). Endotoxin, toxic substance bound to the bacterial cell wall and released when the bacterium ruptures or disintegrates. Endotoxins consist of lipopolysaccharide and lipoprotein complexes. The protein component determines its foreign (antigenic) nature; the polysaccharide component determines the.

Endotoxin is a complex lipopolysaccharide (LPS) that is a major part of the gram-negative bacteria cell wall. Endotoxins are especially abundant in the gut, the tissue source for small intestinal submucosa (SIS). The FDA standard for a biologic scaffold eluate is EU/mL, and EU/mL for devices intended for cerebrospinal applications. This source expertly examines the discovery, biological structure, control, and continued clarification of endotoxin from a parenteral manufacturing perspective, with in-depth discussion of state-of-the-art technologies involving Limulus amebocyte lysate (LAL) such as assay development, automation, depyrogenation. Completely revised and expCited by:   Purchase Bacterial Endotoxins - 1st Edition. Print Book & E-Book. ISBN , Book Edition: 1. endotoxin [en´do-tok″sin] a heat-stable toxin associated with the outer membranes of certain gram-negative bacteria, including Brucella, Neisseria, and Vibrio species. Endotoxins are not secreted but are released only when the cells are disrupted; they are less potent and less specific than the exotoxins; and they do not form toxoids. In large.

International Symposium on Endotoxins ( Jichi Medical School). Endotoxin. New York: Plenum Press, © (OCoLC) Material Type: Conference publication, Internet resource: Document Type: Book, Internet Resource: All Authors / Contributors: Herman Friedman. Lipopolysaccharides (LPS), also known as lipoglycans and endotoxins, are large molecules consisting of a lipid and a polysaccharide composed of O-antigen, outer core and inner core joined by a covalent bond; they are found in the outer membrane of Gram-negative bacteria.. The term lipooligosaccharide ("LOS") is used to refer to a low-molecular-weight form of bacterial lipopolysaccharides. About this Item: CBS Publishers & Distributors Pvt. Ltd, Hardcover. Condition: New. 3rd edition. This source expertly examines the discovery, biological structure, control, and continued clarification of endotoxin from a parenteral manufacturing perspective, with in-depth discussion of state-of-the-art technologies involving "Limulus" amebocyte lysate (LAL) such as assay development.   Too many endotoxins in the bloodstream disrupt the functioning of the immune system. This is the trigger and the source of virtually every chronic and neurological disease. When they overwhelm the immune system with too many endotoxins in the bloodstream it is more of an instant kill rather than death by a thousand cuts.